间质性肺疾病与胃食管反流

Interstitial lung disease and gastro-esophageal reflux

胃食管反流可以引起慢性咳嗽和哮喘，除此之外胃食管反流和一些间质性肺疾病，如特发性肺纤维化、闭塞性细支气管炎伴机化性肺炎、结缔组织疾病中的系统性硬化相关性肺疾病等也存在比较明显的关系，胃食管反流在上述疾病中高发。虽然胃内容物造成的肺组织损伤在动物实验中已得到证实，但是胃食管反流与间质性肺疾病的明确关系还需要更深入的研究和实验来阐明。本文主要综述近年来关于胃食管反流与间质性肺疾病关系的研究进展。

Gastro-esophageal reflux（GER） has been identified as one cause of cough and asthma. In addition,GER may be associated with some interstitial lung diseases（ILD）, such as idiopathic pulmonary fibrosis, bronehiolitis obliterans organizing pneumonia and systemic sclerosis. Lung injury caused by pulmonary aspiration of gastric contents has been shown in animal models. But the further study and trial are needed to clarify the correlation between GER and ILD. This review includes the recent researches about the association of GER and ILD.