血必净对严重烧伤患者血清C反应蛋白及脓毒症发生的影响

Serum Level of C Reactive Protein and Incidence of Sepsis in Patients with Severe Burn Treated with Xuebijing Injection

目的:观察血必净注射液对严重烧伤患者血清C反应蛋白(C-reactive protein CRP)及脓毒症发生的影响。方法:将严重程度相当的重度以上烧伤住院患者80例随机分为治疗(n=40)和对照组(n=40)。对照组按烧伤常规治疗;治疗组在对照组治疗的基础上加用中药血必净注射液,每次100mL静脉滴注,每日1次,连续使用14d。观察2组患者治疗前及治疗后3、7、14d血清CRP变化,并统计2组脓毒症发病率。结果:治疗7d后,治疗组患者CRP较对照组显著下降(P<0.01);脓毒症发病率显著低于对照组(P<0.05)。结论:血必净注射液可降低严重烧伤患者血清CRP水平,显著降低严重烧伤患者脓毒症的发病率。

OBJECTIVE： To observe the effects of Xuebijing injection on serum level of C reactive protein （CRP） and the incidence of sepsis in patients with severe burn. METHODS： Eighty cases with severe burn injury were randomly assigned to receive routine therapy alone （control group, n = 40） routine therapy in combination with Xuebijing injection 100 mL q.d （treatment group, n = 40） for 14 days. The level of CRP at 0, 3, 7, and 14 days were recorded and the incidences of sepsis in the two groups were analyzed statistically. RESULTS： At 7 days, the level of CRP in the treatment group was significantly lower than in the control group（P〈 0.01） .The incidence of sepsis in the treatment group was significantly lower than in control group（P〈 0.05）.CONCLUSION：Xuebijing injection could markedly lower the serum level of CRP and significantly reduce the incidence of sepsis in patients with severe burn.