新生儿肺炎疗效及肠道微生态变化的研究

Efficacy of two antibiotics in the treatment of neonatal infectious pmeumonia and their influence on intestinal microflora

目的观察新生儿感染性肺炎常用的抗生素的疗效以及抗生素对肠道微生态的影响。方法以新生儿感染性肺炎患者为研究对象,按抗生素的使用不同而分组,以各项观察项目全部正常的时间作为肺炎病程终止时间,比较各观察组的治愈率并进行时间一效应分析。分析使用抗生素3、7d时肠道茵群中细菌的含量,以了解抗生素对肠道菌群影响情况。结果①青霉素组、头孢组、联合用药组的治愈率以及时间一效应分析的结果差异无显著性;②使用抗生素对新生儿肠道菌群有影响,其影响随着抗生素使用时间的增加而增大;③3个观察组对肠道微生态的影响以青霉素与头孢菌素联合使用组最为明显,头孢菌素组次之,青霉素组最小。结论治疗新生儿感染性肺炎,青霉素类抗生素的疗效不差于头孢类,仍值得推广应用。联合用药并不优于单用青霉素,抗生素使用种类越多,用药时间越长,对肠道微生态的影响越大,且以头孢类影响大于青霉素类。

Objective To evaluate the efficacy of commonly used antibiotics and their influence on intestinal microflora. Methods The patients with neonatal infectious pmeumonia were divided into two groups according to the used antibiotics, the curative rate and duration of treatment were compared between two groups, to explore the changs of intestinal microflora, total amount of bacteria was examined at 3 or 7 days after treatment. Results There was no significant difference on curative rate and duration of treatment between two groups. The influence of antibiotics on intestinal microflora increased with the duration of treatment. The influence antibiotics on intestinal microflora varied, combination of penicillin and cynnematin showed the most effect, eynnematin showed moderate effect, penicillin had the least effect. Conclusion The treatment of neonatal infectious pneumonia, the efficacy of antibiotics penicillin not inferior to cephalosporins, is still worthy of popularization. Combination therapy is not superior to penicillin alone, more types of antibiotics used, the longer the drug, the greater the impact of gut microflora, and the impact to cephalosporins than penicillins.