摘要
目的分析β-内酰胺类抗菌药物不良反应(ADR)发生的特点,为临床合理用药提供参考。方法采用回顾性调查方法对本院2005～2008年度收集到的125份β-内酰胺类抗菌药物不良反应报告进行统计学分析,归纳总结出β-内酰胺类抗菌药物不良反应发生一般规律和有关特征。结果4年间共收到181份ADR报告,其中由β-内酰胺类抗菌药物引起的ADR125例占69.06%,病例报告中涉及18种β-内酰胺类抗菌药物,主要为头孢曲松钠(24例)、青霉素钠(20例)和头孢噻肟钠(13例)。ADR累及人体的14个系统,表现以皮肤及附件损伤最为常见,其次为心血管系统、消化系统等。结论应合理使用β-内酰胺类抗菌药物,重视ADR的监测工作,避免和减少ADR的发生。
Objective To monitor and analyze the characterization of adverse drug reaction （ADR） associated withβ-lactam antibiotics for rational drug use. Methods 125 ADR cases induced by β-lactam antibiotics collected in our hospital during 2005 - 2008 were analyzed retrospectively to summarize the regulation and features of ADR induced byβ-Lactam. Results There were 181 case reports of adverse drug reaction （ADR） during four years, and 69. 06% were induced byβ-Lactam. 18 drugs were in 125 ARD case reports, including cefrtiaxone soduim （24 cases）, benzylpenicillin sodium （24 cases） and cefotaxime sodium （ 13 cases）. ADR occurred in 14 systems of human beings. The most common displays of ADR were the lesion of skin and the appendants, followed by the lesion of cardiovascular system and digestive system etc. Conclusion It is advisable to promote rational use of β-lactam antibiotics and strengthen ADR monitoring so as to decrease or avoid the occurrence of ADR.
出处
《中国实用医药》
2009年第21期17-19,共3页
China Practical Medicine
