糖尿病周围神经病变的临床分析及震动感觉阈值测定

A Clinical Analysis and Vibration Perception Threshold Determination of Diabetic Peripheral Neuropathy

目的分析糖尿病(DM)患者临床特点及双足的的震动感觉阈值(VPT)。方法收集218例糖尿病患者临床资料,并进行震动感觉阈值测定。结果与无症状组相比,有症状组的年龄更大,糖尿病病程病程更长,糖尿病视网膜病变患患者数更多,24h尿白蛋白定量及震动感觉阈值更高(P<0.05)。多元线性回归分析提示两组患者的震动感觉阈值与患者糖尿病病程、24h尿白蛋白定量相关(P<0.05)。根据症状诊断,DPN患病率为43.1%,根据VPT检测结果诊断,DPN患病率为57.8%。结论糖尿病周围神经病变和糖尿病病程相关;震动感觉阈值测定能早期诊断糖尿病周围神经病变。

Objective To analyze type 2 diabetes mellitus （T2DM） patients＇ clinical features and feet＇ s vibration perception threshold （VPT）. Methods Collecting 218 cases of patients with type 2 diabetes＇ clinical data, and determining their vibration perception threshold. Results Compared with the asymptomatic group, symptomatic group has greater age, longer duration of diabetes, more numbers of patients with diabetic retinopathy, higher 24-hour urinary albumin quantitative and vibration perception threshold. （ P 〈 0. 05 ）. Multiple linear regression analysis showed that two groups of patients＇ vibration perception threshold was related to diabetes duration, 24-hour urinary albumin quantitative （P 〈 0. 05 ）. Based on symptoms, DPN prevalence rate was 43. 1% ;according to VPT, DPN prevalence rate was is 57. 8%. Conclusion Diabetic peripheral neuropathy was related to the duration of diabetes; Diabetic peripheral neuropathy can be diagnosed earlier with vibration perception threshold.