脑源性神经营养因子基因多态性与抑郁障碍激越行为的关系
被引量:1
摘要
抑郁障碍是一种常见的精神疾病,其终生患病率为12%-17%、遗传度为40%~50%。国外研究表明脑源性神经营养因子(BDNF)在抑郁障碍的遗传学研究中起着不可忽视的作用。其对大脑神经元的生长维护、发育以及可塑性等作用至关重要。有研究显示编码区rs6265多态性与抑郁障碍自杀观念、焦虑症、强迫症以及进食障碍等疾病有关。此外动物研究发现携带有Met/Met的小鼠在应激环境中容易出现焦虑行为。已有惟一一项研究显示BDNF基因与汉族人群抑郁症严重程度及其症状群不相关(152例)。本研究立足中国北方汉族人群,在大样本(455例)研究中开展BDNF基因rs6265多态性和rs7124442多态性与抑郁障碍临床症状的关联性研究。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第27期1936-1938,共3页
National Medical Journal of China
基金
国家自然科学基金项目(30770770、30721063)
国家人事部留学回国人员科研资助项目(2007)
山西省青年科技研究基金(2007021050)
国家“863”计划(2006AA02A407)
科技部国际合作项目(2006DFA31440)
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