摘要
目的:观察结直肠癌病人应用短肽肠内营养(百普素)制剂辅助术前肠道准备的效果、相关营养指标以及对肠功能和术后免疫功能的影响。方法:将60例结直肠癌病人随机分为试验组和对照组,每组各30例。试验组病人于术前3天至术后第7天给予口服百普素营养支持,对照组病人入院后采用传统方式术前常规膳食、清洁灌肠法和术后PN营养支持。两组病人分别于术前1天、术后第1、3、7天分别检测ALB、Hb、免疫球蛋白(IgG、IgA、IgM)、T淋巴细胞亚群(CD3+、CD4+、CD4+/CD8+)水平,观察两组病人术中肠黏膜和肠道清洁情况,术后营养状况、免疫功能、感染性并发症和住院时间的差异。结果:两组病人术中肠黏膜状况、肠道清洁度无显著性差异;术后两组病人各项营养指标和免疫指标水平均有不同程度下降,但试验组下降幅度明显低于对照组(P<0.01)。试验组病人术后第7天IgG、IgA、IgM明显高于对照组(P<0.01),术后感染性并发症的发生率低于对照组(P<0.01),术后平均住院时间较对照组缩短(P<0.01)。结论:结直肠癌病人围手术期应用短肽肠内营养制剂,更有利于营养状况和术后免疫功能的恢复,改善预后。
Objective： To observe the effect of peptisorb on the resuh of intestinal preparation, the change of correlated nutritional index, the ruction of intestine and the immune function after operation in perioperative colorectal cancer patients. Methods： sixty patients were randomly allocated into two groups. The trial group （ n = 30 ） received peptisorb 3days before and 7days after operation. Control group （n = 30） received coloclysis treatment. The the level of Alb, globulin, the number of IgG, IgA, IgM, CD3^＋ ,CD4^＋/ CD8^＋,the station of intestinal mucosa and intestine cleaning during operation, nutritional state after operation, immune function, infcetious complications, length of stay were detected. Results： There were no significant difference in the station of intestinal mucosa and intestine cleaning. The index of nutritional and immune in two groups were descend, but the trail group was better （P 〈0.01 ）. The number of IgG, IgA, IgM, CD3^＋ in the trail group were significantly higher than the control group （P 〈 0.01 ）, the rate of postoperative infectious complications in the trail group was lower than the control group. The trail group aslo showed shorter average length of stay after surgery than the control（P 〈 0.01 ）. Conclusion： The peptisorb can ameliorate the host immune function and improve clinical outcome,which is a good nutrition support pathway to perioperative colorectal cance patinets.
出处
《肠外与肠内营养》
CAS
北大核心
2009年第4期197-200,共4页
Parenteral & Enteral Nutrition
基金
珠海市科技计划资助项目(pC20081021)
