加速康复外科对胃癌手术病人体液免疫和临床指标的影响

Effect of fast tract surgery on humoral immunity and clinical index of gastric cancer patients

目的:探讨加速康复外科(FTS)对胃癌病人体液免疫和临床指标的影响及其合理应用。方法:将56例胃癌病人随机分为FTS组和传统处理组,每组各28例。观察病人术后体液免疫和临床指标。结果:两组病人术后体液免疫均有下降,FTS组病人第1天C3、C4水平为(0.845±0.126)g/L和(0.212±0.070)g/L(P<0.05),术后第3天IgA、IgG、IgM水平分别为(1.603±0.468)g/L、(0.845±0.187)g/L和(9.548±1.920)g/L(P<0.05)。FTS组病人的抗生素使用时间、肛门排气时间、住院时间、术后并发症等指标均好于传统处理组(P<0.01,P<0.05)。结论:FTS对胃癌病人体液免疫影响较小,更有利于术后康复。

Objective ： To investigate the influence of fast tract surgery on the humoral immunity and the chief clinical index of gastric cancer patients. Methods ： 56 patients with gastric cancer from December 2007 to June 2008 were randomly divided into two groups： experiment group（fast tract surgery group, n = 28 ） and control group （ conventional treatment group, n = 28 ）. The changes of serum levels of humoral immunity and the chief clinical index were analysed and compared. Results： The serum levels of humoral immunity in both group were decreased. The serum levels of C3 and C4 on the postoperative 1st day were（0. 845 ±0. 126）g/L and（0.212 ±0.070） g/L respectively（P 〈0.05） in FTS group. The serum levels of IgA, IgM and IgG on the postoperative 3rd day were（ 1. 603± 0. 468 ） g/L, （0. 845 ±0. 187 ）g/L, （9. 548 ± 1. 920） g/L respectively（ P 〈 0.05 ） in FTS group. The duration of antibiotic use, first passage of flatus, the lengh of hospital stay, the occurance of postoperative complications in FTS group were also significiantly lower than those in control group （ P 〈 0. O1, P 〈 0. 05 ）. Conclusion ： Fast tract surgery affectes on the humoral immunity of gasrtic cancer patients, and it might contribute to the improved outcomes of postoperative patients.