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TRPC6高表达对小鼠足细胞裂孔隔膜分子和细胞骨架的影响 被引量：4

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摘要 瞬时受体电位阳离子通道蛋白6（TRPC6）是新近发现的联系足细胞裂孔隔膜与细胞骨架的重要分子，TRPC6功能异常在遗传性及获得性蛋白尿性肾小球疾病蛋白尿的发生、发展中起重要作用。本研究观察了TRPC6高表达对体外培养的小鼠足细胞nephrin、α-actinin-4、α-tubulin分布及表达的影响，以期进一步揭示TRPC6高表达的致病机制。
作者 孙希锋 张春 方展 朱忠华 杨晓 姜华军 何方方
机构地区 华中科技大学同济医学院附属协和医院肾内科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2009年第7期519-521,共3页 Chinese Journal of Nephrology
基金 国家自然科学基金（30500245,30871147） 湖北省卫生厅科研基金（NX200510）
关键词 细胞骨架 裂孔隔膜 足细胞 膜分子 小鼠 Α-TUBULIN nephrin 肾小球疾病
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献5

  • 1Mundel P,Reiser J,Zuniga Mejia Borja A,et al.Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.Exp Cell Res,1997,236:248-258.
  • 2姜华军,张春,朱忠华,刘建社,邓安国.CD2相关蛋白在肾脏固有细胞中的表达及分布[J].中华肾脏病杂志,2007,23(6):404-405. 被引量：5
  • 3Reiser J,Polu KR,Moller CC,et al.TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.Nat Genet,2005,37:739-744.
  • 4Winn MP,Conlon PG,Lynn KL,et al.A Mutation in the TRPC6 cation channel causes familial focal segmental glomeruloscleioses.Science,2005,308:1801-1804.
  • 5Moller CC,Wei C,Altintas MM,et al.Induction of TRPC6 channel in acquired forms of proteinuric kidney disease.J Am Soc Nephrol,2007,18:29-36.

二级参考文献7

  • 1Shih NY, Li J, Karpitskii V, et al. Congenital nephritic syndrome in mice lacking CD2-associated protein. Science, 1999, 286(5438): 312-315.
  • 2Shih NY, Li J, Cotran R, et al. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel c-terminal domain. Am J Pathol, 2001, 159: 2303-2308.
  • 3Lehtonen S, Zhao F, Lehtonen E. CD2-associated protein directly interacts with the actin cytoskeleton. Am J Physiol Renal Physiol, 2002, 283: F734-F743.
  • 4Mundel P, Reiser J, Borja AZ, et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res, 1997, 236: 248-258.
  • 5Smoyer WE, Mundel P. Regulation of podocyte structure during the development of nephritic syndrome. J Mol Med, 1998, 76: 172-183.
  • 6Saleem MA, Ni L, Witherden L, et al. Co-localization of nephfin, podocin, and the actin cytoskeleton. Am J Pathol, 2002, 161: 1459-1466.
  • 7Coward RJM, Foster RR, Patton D, et al. Nephrotic plasma alters slit diaphragm-dependent signaling and translo cates nephrin, podocin, and CD2-associated protein in cultured human podoeytes. J Am Soc Nephrol, 2005, 16: 629-637.

共引文献4

同被引文献39

  • 1张丽芬,黄文政,朱小棣,王耀光.阿霉素肾病肾小球硬化动物模型的研究[J].中国中西医结合肾病杂志,2005,6(4):195-199. 被引量：55
  • 2Fukasawa H, Bomheimer S, Kudlicka K, et al. Slit diaphragms contain tight junction proteins. J Am Soc Nephrol,2009,20:1491- 1503.
  • 3Kim EY, Dryer SE. Effects of insulin and high glucose on mobilization of slol BKCa channels in podocytes. J Cell Physiol, 2011,226:2307-2315.
  • 4Lim SK, Park SH. The high glucose-induced stimulation of B1R and B2R expression via CB (1)R activation is involved in rat podocyte apoptosis. Life Sci,2012,91:895-906.
  • 5Tuttle KR. Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease. J Am Soc Nephrol, 2005, 16:1537-1538.
  • 6Dandona P,Aljada A, Chaudhuri A, et al. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation ,2005,111 : 1448-1454.
  • 7Yu L, Lin Q, Liao H, et al. TGF-131 induces podocyte injury through Smad3-ERK-NF-KB pathway and Fyn-dependent TRPC6 phosphorylation. Cell Physiol Biochem, 2010, 26: 869-878.
  • 8Winn MP, Conlon PJ, Lynn KL, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science, 2005, 308: 1801- 1804.
  • 9Mo|ler CC, Wei C, Altintas MM, et al. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol 2007,18:29-36.
  • 10Yu Y, Keller SH, Remillard CV, et al. A functional single- nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation, 2009,119 : 2313-2322.

引证文献4

二级引证文献11

中华肾脏病杂志
2009年 第7期

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