黄芪颗粒对哮喘病儿外周血淋巴细胞及细胞因子的影响

Effect of radix astragali particles on peripheral blood lymphocytes and cytokines in children with asthma

目的:主要研究黄芪颗粒对急性发作期哮喘病儿临床疗效、外周血淋巴细胞及细胞因子水平的影响。方法:将急性发作期哮喘病儿随机分成治疗组和对照组,治疗组哮喘病儿在给予常规治疗的基础上加服黄芪颗粒,对照组采用单纯西药治疗。检测治疗前、后病儿外周血CD4、CD8、白细胞介素4(IL-4)和白细胞介素12(IL-12)水平。结果:治疗组总有效率明显高于对照组。治疗后治疗组与对照组比较CD4+上升,CD8+下降,CD4+/CD8+升高(P<0.05);治疗后治疗组IL-4较治疗前明显下降(P<0.01),IL-12明显上升(P>0.05),与对照组比较IL-4、IL-8差异无统计学意义(P>0.05)。结论:黄芪颗粒能有效调节哮喘患儿T细胞亚群和细胞因子,较好的辅助治疗小儿哮喘。

Objective： To investigate the clinical efficacy and effect of radix astragali particles on peripheral blood lymphocytes and cytokines in children with acute exacerbation asthma. Methods： The children with acute exacerbation asthma were randomly divided into two groups： treatment group were treated with conventional therapy and radix astragali particles, while control group were treated with Western medicine only. The levels of CD4, CD8, IL-4 and IL- 12 were detected before and after treatment. Results： The total effective rate in treatment group was significantly higher than that in control group. After treatment, compared to control group, the level of CD4^＋ and CD4^＋ / CD8^＋ ratio increased, the level of CD8^＋ decreased in treatment group （P 〈 0. 05） ; in treatment group, the level of IL - 4 after treatment was lower than that before treatment （P 〈 0. 01 ）, the level of IL- 12 reversed （P 〉 0.05 ）, but there was no difference in the levels of IL - 4, IL - 8 between treatment group and control group （ P 〉 0. 05 ） . Conclusion： Radix astragali particles can regulate T cell subsets and cytokines, which is a good adjunctive therapy for children with asthma.