探讨血清孕酮(P)与米非司酮在异位妊娠保守治疗中的应用关系

Discussion blood serum progesterone (P) and mifepristone in extrauterine pregnancy conservative treatment application relations

目的:探讨血清孕酮(P)与米非司酮在异位妊娠保守治疗中的应用关系。方法选取2006年1月至2007年12月两年时间共收治的异位妊娠保守治疗的病人中78例进行分组研究,均符合异位妊娠保守治疗条件。治疗前行血清孕酮值测定:≤8ng/ml(24.96nmol/ml),并以8ng/ml(24.96nmol/ml)为用药界定值,一组42人为研究组,另一组36人为对照组,研究组单用氨甲喋呤治疗,对照组以米非司酮与氨甲喋呤联合治疗,疗程结束判定治疗效果。结果两组治疗效果差异无显著性意义。结论米非司酮的疗效与血清孕酮有明显的量效相关性,在血清孕酮值低至8ng/ml(24.96nmol/ml)时,单用氨甲喋呤即可达到治疗目的,使用米非司酮不能发挥其抗早孕效应,而失去应用价值,可不用米非司酮。

Goal Discussion blood serum progesterone （P） and mifepristone in extrauterine pregnancy conservative treatment application relations. Method Selects January, 2006 in the extrauterine pregnancy conservative treatment patient who two years altogether admits to the December, 2007 78 examples to conduct the grouping research, meets the extrauterine pregnancy conservative treatment condition. Treats the vanguard blood serum progesterone value determination： ≤ 8ng/ml （24.96nmol/ml） , and take 8ng/ml （24.96nmol/ml） as the medication limits value, group of 42 artificial study teams, another group of 36 artificial control groups, study team Shan Yongan the armor die ling treat, control group by mifepristone and ammonia armor die ling union treatment, treatment course conclusion determination treatment result.Result Two group of treatment result difference non-significance significance.Conclusion mifepristone＇s curative effect and the blood serum progesterone has the obvious quantity effect relevance, when the blood serum progesterone value lowers to 8ng/ml （24.96nmol/ml） , Shan Yongan the armor die ling then serves the treatment purpose, uses mifepristone not to be able to display its anti-early pregnancy effect, but loses the application value, but does not use mifepristone