地氯雷他定的分子印迹聚合物的制备及其吸附性研究

Synthesis and Characterization of Molecularly Imprinted Polymer of Desloratadine

目的:以地氯雷他定为模板分子,分别用甲基丙烯酸(MAA)、丙烯酰胺(AM)和两者(1:1)的混合物为功能单体制备了相应的聚合物。方法:将模板分子、功能单体、交联剂,按1:4:20比例制备相应的分子印迹聚合物,再将制得的棒状聚合物经过研磨、过筛后,采用平衡结合方法评价了该分子印迹聚合物的吸附结合特性。结果:研究表明,采用MAA为功能单体,以乙酸乙酯做溶剂合成的地氯雷他定MIP对模板分子的结合性最佳。结论:地氯雷他定MIP作为固相萃取填料,在临床体液样品中对地氯雷他定的富集和检测有应用前景。

Objective. To select a suitable functional monomer to synthesize molecular. Methods. Molecular imprinted polymers were synthesiged with MAA, AAM and MAA-AAM（I：I） as functional monomers in different solution, using UV as a detechion. Results： The polymer taking MAA as functional monomer and acetic ether as solvent obtained higher selectivity for desloratadine. Conclusion： Molecular imprinted polymers exhibit clinical utility for enrichment and determination of trace desloratadine.