Rho/Rho激酶信号通路与血管内皮通透性的研究

Rho/Rho-kinase Signalling Pathways and Vascular Endothelial Permeability

Rho/Rho激酶信号通路是体内普遍存在的一条信号通路,它通过调节细胞内肌动蛋白骨架的聚合状态而扮演着"分子开关"的角色,参与细胞形态维持、细胞粘附与迁移、细胞增殖与凋亡、基因转录、平滑肌收缩等多种生物学行为。Rho/Rho激酶信号通路在血管内皮通透性的病理生理过程中发挥了重要作用,抑制Rho/Rho激酶信号通路取得了显著的内皮保护作用。

Rho/Rho- kinase signaling pathway is a ubiquitous one in vivo. It plays a role of ＂molecular switch＂ by regulating the polymetic state of intracellular actin cytoskeleton and participates in the regulation of various cellular functions, including cell polarity, cell adhesion and migration, cell proliferation and apoptosis, genetic transcription, smooth muscle cell contraction. Rho/Rho - kinase signaling pathway plays an important role in vascular endothelial permeability in pathophysiological condition. Inhibition of Rho/Rho - kinase signaling pathways may achieve a significant endothelium protective effect.