丹参注射液联合硫酸镁对妊娠高血压综合征患者血管活性物质及肾功能的影响

The effect of injection salvia miltiorrhiza plus magnesium sulfate on vasoactive substance and renal function in women with pregnancy-induced hypertension syndrome

目的探讨丹参注射液联合硫酸镁对妊娠高血压综合征（PIH）患者血管活性物质一氧化氮（NO）、内皮素-1（ET-1）、血栓素A2（TXA2）、前列环素I2（pGl2）及肾功能的影响。方法将54例PIH患者随机分为两组，硫酸镁治疗组（对照组，27例）和丹参注射液联合硫酸镁治疗组（观察组，27例），观察两组患者治疗后NO、ET-1、TXA2、PGI2及α1-微球蛋白（α1-MG）、血尿素氮（BUN）、肌酐（Cr）的变化。结果治疗后观察组和对照组NO、ET-1、TXA2、PG12分别为（985．43±224．17）nmol／L、（53．52±3．88）ng/L、（426．33±26．52）pg／L、（277．34±14．06）pg／L和（832．35±192．43）nmol／L、（61．43±3．56）ng／L、（472．24±22．28）pg／L、（202．12±11．56）pg／L，与治疗前比较差异均有统计学意义（P〈0．05），观察组优于对照组，差异均有统计学意义（P〈0．05）。治疗后两组肾功能与治疗前比较差异均有统计学意义（P〈0．05），观察组优于对照组，差异均有统计学意义（P〈0．05）。结论丹参注射液联合硫酸镁对改善PIH患者NO、ET-1、TXA2、PGI2比例失调有较好的效果，且具有保护肾功能的作用。

Objective To explore the effect of injection salvia miltiorrhiza plus magnesium sulfate on plasma concentrations of nitric oxide（ NO ）, endothelin -1 （ET-1）, thromboxan A2 （TXA2）, prostaglandin I2 （PGI2）and renal function in women with pregnancy-induced hypertension syndrome （PIH）. Methods Fifty-four women with PIH were randomly divided into magnesium sulfate treated group （27 cases, control group ）and injection salvia miltiorrhiza plus magnesium sulfate treated group （27 eases, observe group ）. The levels of NO, ET-1, TXA2, PGI2 and renal function parameters such as α1-mieroglobulin （ α 1-MG）, blood urea nitrogen （BUN）and creatinine （Cr）were measured. Results The NO, ET-1, TXA2, PGI2 were （985.43 ±224.17） nmol/L, （53.52 ±3.88） ng/L, （426.33 ±26.52） pg/L, （277.34 ± 14.06） pg/L and （832.35 ± 192.43） nmol/L,（61.43 ±3.56） ng/L,（472.24 ±22.28） pg/L, （202.12 ± 11.56） pg/L in two groups respectively. There was significant difference on the levels of NO, ET-1, TXA2 between before and after treatment in two groups（P 〈 0.05 ）, and the observe group was better than the control group （P 〈 0.05 ） . There were significant difference on the levels of α1-MG, BUN and Cr between before and after treatment in two groups （P 〈 0.05 ）. The renal function in the observe group was improved greater than that in the control group （P 〈 0.05 ）. Conclusions Injection salvia miltiorrhiza plus magnesium sulfate treatment can well balance the plasma concentration levels of NO, ET-1, TXA2 and PGI2 in women with PIH. It has protective effect on renal function.