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缺血后适应对家兔缺血再灌注心肌细胞凋亡的影响

The effect of post-conditioning on cardiomyocytes apoptosis during ischemia/reperfusion injury in rabbits
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摘要 目的探讨缺血后适应对兔短期缺血再灌注心肌细胞凋亡的影响。方法32只新西兰大白兔随机分成4组:对照组、假手术组、缺血再灌注组(IR组)、缺血后适应组。IR组左冠状动脉前降支15min阻断和30min再灌注,缺血后适应组在15min缺血后接受连续3次每次再灌注30s,缺血30s的后适应。TUNEL法检测心肌组织的细胞凋亡情况。结果TUNEL检测结果:缺血后适应组心肌细胞凋亡指数为(23.5%),与IR组(36.2%)相比,显著降低差异有统计学意义(P<0.01)。结论缺血后适应显著减轻了兔缺血再灌注诱导的心肌细胞凋亡,具有心肌保护作用。 Objective To explore the effect of postcond1tioning on cardiomyocytes apoptosis during ischemia/reperfusion injury in rabbits. Methods 32 rabbits were randomly divided into three groups:the control,sham,ischemia reperfusion group and post-conditioning group. Left anterior descending artery was occluded for 15 min followed by 30 min reperfusion in IR group. In post-groups,at the start of reperfusion,three cycles of 30 sec perfusion and 30sec reocclusion preceded the 30 min of reperfusion. TUNEL was used to access cardiomyocytes apoptosis. Results The apoptosis index was 23.5% in post-conditioning group,which was significantly decreased compared with that in IR group (36.2%,P〈0.01). Conclusion Post-conditioning has protective effect in cardiomyoctes apoptosis induced by ischemia/reperfusion injury in rabbits.
出处 《中国实用医药》 2009年第6期76-77,共2页 China Practical Medicine
关键词 缺血 再灌注 后适应 凋亡 损伤 心肌 Ischemia Reperfusion Post-conditioning Apoptosis Injury Myocardio
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  • 1F. Kerendi MD,H. Kin MD,M. E. Halkos MD,R. Jiang PhD,A. J. Zatta PhD,Z.–Q. Zhao PhD,R. A. Guyton MD,J. Vinten–Johansen PhD. Remote postconditioning[J] 2005,Basic Research in Cardiology(5):404~412

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