N,N＇-二{亚烷基氧羰基苯基-5-[10，15，20-三(4-氯苯基)]卟啉基}-5-氟尿嘧啶的合成与表征

Synthesis and Characterization of N,N'-bis{alkyleneoxocarbonylphenyl-5-[10,15,20-tri(4-chlorophenyl)]porphyrin-5-fluorouracil

用对氯苯甲醛和对羧基苯甲醛为原料,合成了周边含羧基苯基的不对称卟啉中间体,然后再与5-氟尿嘧啶反应,合成了两种亚烷基链长不同的标题化合物,产率为22.1%和19.8%。产物结构由元素分析、红外光谱、紫外可见光谱、核磁共振谱和质谱表征确认。同时对目标化合物的合成条件进行了研究,结果表明,在以DMF为溶剂、反应温度在125℃、反应时间8h条件下,反应产率较高。

Using p-chlorobenzaldehyde and p-carboxylbenzaldehyde as the starting materials, the porphyrin intermediate containing carboxyphenyl in peripheral was synthesized, then it was reacted with 5-fluorouracil, the titled compounds with different alkylene length were synthesized with yields 22.1% and 19.8%, respectively. The structures of the products were characterized by elemental analysis, UV-Vis, IR, ^1 H NMR and MS. The results showed that the yield was higher when DMF was used as the solvent at 125℃ for 8h.