急性脑梗死患者肺炎衣原体感染与血脂、C反应蛋白、纤维蛋白原相互关系的研究

Relationship between chlamydia pneumoniae infection and serum levels of lipid,fibrinogen and C-reaction protein in patients with acute cerebral infarction

目的:了解急性脑梗死患者肺炎衣原体(Cpn)感染与血脂、C反应蛋白(CRP)、纤维蛋白原(FIB)的相互关系,探讨其可能的发病机制。方法:应用多聚合酶链反应(PCR)技术检测了100例急性脑梗死患者血清Cpn DNA,选100例非脑梗死患者作为对照组,同时用全自动生化仪检测血脂,免疫透射比浊法检测CRP,凝固法检测FIB。结果:急性脑梗死组Cpn DNA阳性率为68%,对照组Cpn DNA阳性率为38%,两组Cpn DNA阳性率比较差异有显著性(P<0.01)。脑梗死组Cpn阳性患者血脂水平:TC(6.5±1.02)mmol/L,TG(2.11±1.48)mmol/L,LDL-C(3.45±0.46)mmol/L,HDL-C(1.02±0.40)mmol/L;对照组TC,TG,LDL-C,H DL-C水平分别为(4.80±1.12)mmol/L,(1.26±0.42)mmol/L,(3.26±0.45)mmol/L,(1.18±0.26)mmol/L;两组CRP水平分别为:(14.5±7.6)mg/L,(6.8±3.3)mg/L;两组FIB水平分别为:(3.8±0.42)g/L,(2.1±0.28)g/L。两组在血脂、CRP、FIB水平比较差异有显著性。结论:急性脑梗死患者肺炎衣原体感染率明显增高,肺炎衣原体感染可能通过影响血脂代谢来增快动脉粥样硬化,并可能通过炎症反应和凝血功能增强在急性脑梗死的发生、进展中发挥重要作用。

Objective：To investigate the relationship between Chlamydia pneumoniae （Cpn） infection and serum levels of lipid, fibrinogen（FIB） and C -reaction protein（CRP） in acute cerebral infarction. Methods：Serum Cpn DNA was examined using polymerase chain reaction（PCR） technique in 100 control subjects and 100 patients with acute cerebral infarction, blood- fat were detected by automatic biochemistry analyze CRP was determined by using immunoturbidometry, FIB was tested by using clotting method. Results：Cpn DNA positive rate was 68% in acute cerebral infarction, Cpn DNA positive rate was 38% in control subjects. There was significant difference in the two groups. There were significant difference in the levels of TC, TG, CRP, FIB between crecbral infarction group and control group （P 〈0. 01 ）. TC,TG,CRP FIB levels in CpnDNA postitive cases were obviously higher than those in CpnDNA negative cases （ P 〈 0.05 ） , but there was no significant difference in HDL - C level （ P 〉 0. 05 ）. Conclusion：Cpn infection rate significantly increase in patients with acute cerebral infarction. Cpn infection may play an important role in the pathogenesis of acute cerebral infarction through inflammation and enhancing the mechanism of blood coagulation.