某县狂犬疫苗免疫接种后抗体水平分析

Analysis of county rabies vaccine antibody levels after immunization

目的:了解不同年龄、性别、季节等因素对疫苗接种免疫效果的影响,为狂犬病的防治提供指导。方法:采用ELISA方法对2006年1月至2008年12月被猫犬抓(咬)伤且全程足量注射狂犬疫苗者7045例进行抗体检测及分析。结果:7045例观察对象抗体平均阳性率为95.3%。各年龄段的血清抗体水平不同,季节和性别对抗体水平无明显影响。结论:受动物致伤后要及时全程注射狂犬疫苗,免疫后检测血清抗体水平十分重要,对暂未产生抗体者要及时加强免疫,确保免疫效果。

Objective：To investigate the influence of different season, age, sex and other factors on the vaccine inoculation effect to provide the instruction on the prevention and treatment of rabies. Methods：The antibody level after inoculating rabies vaccine in 7045 patients bitten by dogs or cats during the period from Jan 2006 to Dec 2008 were detected by enzyme linked immunosorbent assay （ELISA）. Results：The average positive rate of rabies＇ antibody was 95.3 % in all 7045 patients and the antibody level was strongly associated with age, but was not effected by season and sex. Conclusion：It is important for the patients bitten by dogs or cats to inject rabies vaccine timely and dose fully, as well as to detect the serum antibody level. In addition, it is necessary for patients who don＇t emerge associate antibody to do booster immunization for ensuring immune effectiveness.