复方甲氧那明胶囊与依诺沙星联用患者出现茶碱轻度中毒

Mild theophylline poisoning occurring in a patient receiving compound methoxyphenamine capsules combined with enoxacin

1例67岁男性因慢性阻塞性肺病合并感染,给予复方甲氧那明胶囊(每粒含氨茶碱25 mg)2粒,3次/d;依诺沙星0.2 g,1次/d静脉滴注。5 d后患者出现胸闷、恶心、气急、呕吐数次等症状。停用依诺沙星,3 d后茶碱血浓度为19.06μg/ml。复方甲氧那明胶囊继续使用,上述症状缓解。

A 67-year-old man with chronic obstructive pulmonary disease and infection received 2 compound methoxyphenamine capsules （ each capsule contains aminophylline 25 mg） thrice daily and an IV infusion of enoxacin 0.2 g once daily. After five days of therapy, he developed chest distress, nausea, short of breath, and several times of vomiting. Enoxacin was stopped. Three days later, his serum theophylline concentration was 19. 06 μg/ml. Compound methoxyphenamine capsules were continued. His symptoms mentioned above relieved.