摘要
3例糖尿病患者(男1例,女2例,年龄42～65岁)使用瑞格列奈0.5～2 mg,3次/d。服药前查肝功能正常,服用瑞格列奈1～2个月后,3例均出现皮肤和巩膜黄染,检测肝功能:ALT205～1 350 U/L,AST183～835 U/L,γ-GT155～585 U/L,TBil52.8～158.8μmol/L。经停药和保肝治疗后好转。
Three patients with diabetes mellitus （ 1 man and 2 women aged 42-65 years） received repaglinide 0.5-1 mg thrice daily. Their liver tunctions were normal before repaglinide administration. About 1-2 months of therapy, the patients presented with yellowish skin and sclera. Liver function tests revealed the following values： ALT 205-1 350 U/L, AST 183-835 U/L , γ-GT 155-585 U/L, TBil 52.8-158.8 μmol/L. Repaglinide was stopped and liver - protective treatment was given. Their symptoms subsequently improved.
出处
《药物不良反应杂志》
2009年第3期206-207,共2页
Adverse Drug Reactions Journal
关键词
瑞格列奈
不良反应
肝损害
黄疸
repaglinide
adverse reactions
liver damage
jaundice
