复方肾炎片联合贝那普利治疗慢性肾小球肾炎的研究

Clinical study of Fufang Shenyan pill combined with benazepril in treating chronic nephritis

目的观察复方肾炎片联合贝那普利治疗慢性肾炎蛋白尿的疗效。方法将58例肾功能正常的慢性肾炎患者分为贝那普利(ACEI组)和复方肾炎片联合贝那普利组(联合组),分别检测两组治疗前后24h尿蛋白定量、血压、血肌酐。结果治疗4个月后,联合组临床疗效总有效率(82.76%)显著高于贝那普利组(68.97%)(P<0.05),联合组的24h尿蛋白低于ACEI组(P<0.05),血压、血肌酐两组差异无统计学意义(P>0.05)。结论复方肾炎片联合贝那普利比单用贝那普利能更有效地降低慢性肾炎患者蛋白尿,且安全可靠。

Objective To observe the clinical effect of Fufang Shenyan pill combined with benazepril in the treatment proteinuria of chronic nephritis.Methods 58 patiens were randomly divided into two groups：ACEI group in which 29 patiens were treated by benazepril and combined group in which 29 patiens were treated by Fufang Shenyan pill combined with Benazepril,with a course of 4 months.The clinical effect,24-hour urinary protein,serum creatinine,blood pressure were observed.Results The total effective rate was 82.76% in combined group and 68.97% in ACEI group（P〈0.05）,24-hour urinary protein of combined group was lower than of ACEI group（P〈0.05）.The differences of serum creatinine,blood pressure between the two groups were not significant.Conclusion Fufang Shenyan pill combined with benazepril is more effective in reducing proteinuria of chronic nephritis than individual benazepril.