两种化疗方案在宫颈癌同步放化疗中的疗效及副反应对比分析

Two Different Chemotherapy for Concurrent Chemotherapy and Radiotherapy in Cervial Cancer—analysis of Curative Effect and Toxicity

目的对宫颈癌同步放化疗中的两种化疗方案进行对比研究,探讨更佳化疗方案。方法将我院2004～2005年收治的238例行宫颈癌同步放化疗的患者随机分为BIP方案组(133例)和PF方案组(105例),对他们的2年生存率和毒副反应进行对比研究。结果BIP方案组2年生存率76.7%(102/133),2年无进展生存率70.7%(94/133);PF方案组2年生存率63.8%(67/105),2年无进展生存率57.1%(60/105)。两组比较,差异有统计学意义(P<0.05)。近期毒副反应评价,BIP方案组Ⅲ～Ⅳ度骨髓抑制发生率显著高于PF方案组(P<0.05),远期毒副反应评价经比较差异无统计学意义。结论在宫颈癌同步放化疗的化疗方案中,BIP方案在生存率方面优于PF方案,但骨髓抑制较为严重,在远期毒副反应方面两种化疗方案差异无统计学意义。

Objective Two chemotherapies were compared in order to investigate the better chemothrapy in concurrent chemotherapy and radiotherapy of cervial cancer. Methods Two hundred and thirty-eight patients with advanced cervical cancer were randomly divided into BIP group（133 cases）and PF group （105 cases）. The survival rates and toxicity of these two groups were compared. Results The 2-year survival rate and progression-free survival rate of BIP group was 76.7%（102/133） and 70. 7 % （94/133） respectively. The 2-year survival rate and progression-free survival rate of PF group was 63. 8%（67/105） and 57. l% （60/105） respectively. Signifcant differences were found between these two groups（P〈0. 05）. Ⅲ-Ⅳ degree myelosuppression occurred more frequently in the BIP group than in PF group（P〈0. 05）. However the long-term toxicity of these two groups has no signifcant difference. Conclusion Of the two chemotherapies used in concurrent chemotherapy and radiotherapy of cervix cancer, BIP proceded PF in survival rate, but it has severer marrow toxicity. The long-term toxicity of these two groups has no signifcant difference.