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MAPK信号通路与大肠癌 被引量：2

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作者 季语祝 王芳
机构地区 昆明医学院基础医学院病理学教研室
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2009年第7期623-627,共5页 Cancer Research on Prevention and Treatment
基金 云南省教育厅科研基金资助项目(08J0022)
关键词 信号转导 MAPK 肿瘤 结直肠癌
分类号 R735.34 [医药卫生—肿瘤]
  • 相关文献

参考文献48

  • 1Calvert PM, Frucht H. The genetics of colorectal cancer[J]. Ann Intern Med, 2002,137(7) : 603-612.
  • 2Troppmair J, Bruder JT, Munoz H, et al. Mitogen-activated protein kinase extraeellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradeeanoylphorbol- 13-acetate requires Raf and is necessary for transformation[J]. J Biol Chem, 1994,269(9) :7030-7035.
  • 3Taupin D,Podolski DK. Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation[J]. Gastroenterology, 1999,116(5) : 1072-1080.
  • 4Liu WS, Heckman CA. The sevenfold way of PKC regulation [J]. Cell Signal, 1998,10 (8) : 529-542.
  • 5Chen DB,Davis JS. Epidermal growth factor induces c-los and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independ- ent pathways in bovine luteal cells[J]. Mol Cell Endocrinol, 2003,200(1-2) : 141-154.
  • 6Sato S,Fujita N,Tsuruo T. Involvement of PDK1 in the MEK/ MAPK signal-transduction pathwayEJ-. J Biol Chem,2004,279 (32) : 33759-33767.
  • 7Crew CM,Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product[J].Science,1992,258(5081):478-480.
  • 8Khokhlatchev AV, Canagarajah B, Wilsbacher J, et al. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear transloeation[J]. Cell, 1998, 93 (4) : 605- 615.
  • 9Lavoie JN,L'Allemain G,Brunet A,et al. Cyelin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway [J].J Biol Chem, 1996, 271 (34) :20608-20616.
  • 10Woods D, Parry D, Cherwinski H, et al. Raf-1 induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21^Cip1 [J]. Mol Cell Biol, 1997,17 (9):98-5611.

二级参考文献10

  • 1Jemal A,Siegel R,Ward E,Murray T,Xu J,Smigal C, etal.Cancerstatistics,2006[].CACancerJClin.2006
  • 2Todd W Bauer MD,Fan Fan,BS,et al.Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cellsrequires activation of c-met and urokinase plasminogen activator re-ceptor[].Annals of Surgery.2005
  • 3Kaio E,Tanaka S,Kitadai Y,Sumii M,Yoshihara M,Haruma K,Chayama K.Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma[].Oncology.2003
  • 4Carmeliet P,Jain R K.Angiogenesis in cancer and other diseases[].Nature.2000
  • 5Takahashi Y,Kitadai Y,Bucana CD,Cleary KR,Ellis LM.Expression of vascular endothelial growth factor and its receptor,KDR,correlates with vascularity,metastasis,and proliferation of human colon cancer[].Cancer Research.1995
  • 6Leung, D.W,Cachianes, G,Kuang, W.J,Goeddel, D.V,Ferrara, N.Vascular endothelial growth factor is a secreted angiogenic mitogen[].Science.1989
  • 7Senger,DR,Galli,SJ,Dvorak,AM,Perruzzi,CA,Harvey,VS,Dvorak,HF.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid[].Science.1983
  • 8Cooke,SP,Boxer,GM,Lawrence,L,Pedley,RB,Spencer,DIR,Begent,RHJ,Chester,KA.A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: receptor complex[].Cancer Research.2001
  • 9Slomiany MG,Black LA,Kibbey MM,et al.IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma[].Biochemical and Biophysical Research Communications.2006
  • 10Calza,L,Giardino,L,Giuliani,A,Aloe,L,Levi-Montalcini,R.Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors[].Proceedings of the National Academy of Sciences of the United States of America.2001

共引文献12

同被引文献17

引证文献2

二级引证文献6

肿瘤防治研究
2009年 第7期

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