γ干扰素抗衣原体感染作用的研究进展

Mechanism of interferon-γ-mediated anti-Chlamydia infection

衣原体为专性胞内寄生菌,具有广泛致病谱,是重要的致病菌。γ干扰素在抗衣原体感染中起重要作用,其介导的抗衣原体感染效应机制包括耗竭色氨酸、诱导铁缺失途径以及激活一氧化氮合酶等;但衣原体也有其自身特有的避免γ干扰素干扰的免疫逃避机制。本文综述γ干扰素抗衣原体感染作用机制的研究现状。

Chlamydia is an intracellular bacterium that infects many vertebrates, including humans. Previous studies have shown that interferon-γ, （IFN-γ） plays an important role in defense against Chlamydia infection. IFN-γ mediated anti-Chlamydia effector mechanisms may include the exhaustion of tryptophan, the induction of iron loss, and/or the activation of inducible nitric oxide synthase （iNOS）. However, Chlamydia has evolved to develop mechanisms to escape IFN-γ functions. In this review, we will discuss IFN-γ-mediated effector mechanisms in the control of Chlamydia infection.