基因改变对正常核型急性髓系白血病预后影响的研究进展
摘要
急性髓系白血病（AML）是一组在临床及遗传学上均具有异质性的疾病。在以细胞遗传学为基础的预后分组中，大约45％AML患者的核型是正常的，被列人中危组。但是，这组患者基于不同的分子学特征，其临床结局不尽相同。近期分子学研究显示，因获得性基因突变和基因表达改变的存在导致了该组患者预后的显著异质性，而且，其与白血病的发生机制有关，许多被证实的基因改变已经成为或即将成为特异性治疗靶点。本文就近年来证实的基因改变与白血病形成的关系及其预后影响作一综述。
出处
《国际输血及血液学杂志》
CAS
2009年第4期328-331,共4页
International Journal of Blood Transfusion and Hematology
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