胸腺瘤中VEGF的表达及微血管密度与其胸腺瘤螺旋CT表现的相关性

Correlation of VEGF expression and microvessel density with spiral CT manifestations of thymoma

目的:探讨血管内皮生长因子(VEGF)在胸腺瘤组织中的表达以及微血管密度(MVD)与胸腺瘤螺旋CT(SCT)表现的相关性.方法:84例胸腺瘤经SCT检查,重点观察肿瘤的形态密度、边缘与周围心脏、大血管及纵隔的关系,有无肺转移及胸膜种植;其中40例行增强扫描.所有84例胸腺瘤标本均行免疫组化SP法染色,检测VEGF及MVD表达,并分析其与SCT征象之间的相关性.结果:胸腺瘤组织CT强化幅度随VEGF表达水平和MVD计数的增高有增加的趋势(P<0.01).VEGF表达水平和MVD计数与胸腺瘤CT征象中的分叶征、尖角征/锯齿征、胸膜、心包及大血管侵犯有相关性(P<0.05).而纵隔脂肪线、病灶大小、密度均匀与否及肺内转移等征象与其表达则无统计学意义(P>0.05).结论:SCT征象与VEGF表达及MVD相关,这有利于术前无创性评估肿瘤生物学行为.

AIM： To investigate the correlation of VEGF expression and microvessel density （MVD） with spiral CT （SCT） manifestations of thymoma. METHODS： Eighty-four cases of thymoma received SCT examination, including the appearance and density of the tumors, relationship of the tumor margin with heart, large blood vessels and mediastinum. Forty of the 84 patients underwent enhanced CT. The expressions of VEGF and MVD in all the 84 cases were investigated immunohistochemically. The manifestations of CT findings were carefully reviewed and the correlation with the corresponding expressions of VEGF and MVD was analyzed. RESULTS： SCT images were enhanced with the increase of VEGF expression level and MVD counting（P 〈0.01）. Significant correlation was observed between VEGF expression, MVD counting and some thymoma signs, including lobular contours, cusp angle-like/sawtooth-like margins and the tumoral invasions to pleural membrane, pericardium and great vessels （P 〈0.05）, while no correlation was observed with mediastinal fat line, size and density of the tumor, and lung metastasis （P 〈 0.05）. CONCLUSION： SCT imaging is correlated with the expression of VEGF and MVD and reflects the pathological char-acteristics of thymoma, which is a good noninvasive measure for clinical evaluation of thymoma.