陇中黄土高原地区404例冠状动脉造影与冠心病危险因素相关性分析

A correlation analysis of risk factors of coronary heart disease in loess plateau area of Longzhong

目的:探讨陇中黄土高原地区冠心病患者的发病危险因素,为该地区冠心病的一、二级预防提供科学依据.方法:对404例拟行冠状动脉造影患者可能伴有的危险因素进行询问和检查.结果:①冠状动脉造影显示有病变者303例,无病变者101例.两组的年龄、性别、高血压病、糖尿病、饮酒史、吸烟史、经济收入、生活工作压力、三酰甘油、低密度脂蛋白比较,差异均有显著性(P<0.05～0.01).②年龄、高血压病、糖尿病、吸烟、经济收入、生活工作压力、低密度脂蛋白危险因素与冠状动脉病变范围及冠状动脉受累支数有相关性(P<0.05～0.01).而总胆固醇、高密度脂蛋白、三酰甘油在组间无显著性差异(P>0.05).③冠状动脉造影结果与冠心病危险因素相对危险度(OR值)从大到小排列依次为糖尿病、吸烟、高血压病、血脂异常、饮酒史、生活工作压力、年龄、经济收入和性别.结论:糖尿病、吸烟、高血压病、血脂异常、饮酒史、生活工作压力、年龄、经济收入和性别为冠心病发病的危险因素,糖尿病可能为该地区冠心病的主要危险因素.

AIM：To analyze the risky factors of patients with coronary heart disease （CHD） in the loess plateau of Longzhong （the central part of Gansu Province） for primary and secondary prevention of CHD in this region. METHODS： Totally 404 patients were reviewed and examined on the potential risk factors in the coronary angiograph. RESULTS： Coronary angiography showed coronary artery lesions in 303 patients （ lesion group） and no lesion in 101 patients （non-lesion group）. Significant difference between the 2 groups was observed in age, gender, income, hyper- tension, diabetes mellitus, drinking and smoking history, work and life pressure, triglyceride （TG） and lower-density lipoprotein cholesterol （ LDL-C ） （ P 〈 0. 05 - 0.01 ）. Significant difference was observed between the extent of coronary artery lesions and age, income, hypertension, diabetes mellitns, drinking and smoking history, work and life pressure, and LDL-C（P 〈0.05 -0.01）. No significant difference was found in total cholesterol, HDL-C and TG（P 〉 0.05 ）. Odds ratio （OR） of logistic regression analysis showed that CHD was significantly correlated in a descending order to diabetes mellitus, smoking, hypertension, dyslipidosis, drinking, work and life pressure, age, income, and gender. CONCLUSION： Diabetes mellitus, smoking, hypertension, drinking, work and life pressure, age, gender, income and LDL- C are all risk factors of CHD, among which diabetes mellitus is the major risk factor for CHD in the loess plateau of Longzhong.