受体酪氨酸激酶EphA1 mRNA在胃癌中的表达

Expression of receptor tyrosine kinase EphA1 in gastric cancer and its clinicopathological significance

目的:EphA基因是受体酪氨酸激酶基因家族成员,可能在肿瘤的发生、发展中起重要作用。文中通过检测EphA1基因在正常胃黏膜和胃癌组织中的表达,探索EphA1基因对胃癌发病、进展及预后的作用。方法:用荧光标记实时定量RT-PCR检测56例胃癌患者肿瘤和正常黏膜组织中EphA1 mRNA的表达,分析其差异与临床多项指标之间的关系。结果:EphA1表达下调在直径小于5 cm的肿瘤中多见(P=0.017)。EphA1表达上调多发生于胃癌晚期(P=0.002)及伴有淋巴结转移的患者(P=0.020)。EphA1表达与其他临床指标之间无明显相关。结论:EphA1基因可能具有促进胃癌进展的作用。

Objective：EphA genes are members of receptor tyrosine kinase genes and may have an important role in oncogenic transformation and tumor progression. This study was aimed to analyze the aberrant expression of EphA in gastric cancer and its correlation with clinical parameters, so as to explore the significance of EphA1 in the etiology, progression and prognosis in gastric cancer. Methods：Expression of EphA1 mRNA was determined using quantitative real time RT-PCR in 56 gastric cancer patients. Correlation between gene expression and clinical parameters was measured by Spearman＇ s rho statistic. Results ： Down-expression of EphA was more commonly observed in patients witb tumors smaller than 5cm （P = 0. 017 ）. Over-expression was more commonly observed in more advanced patients （P = 0. 002 ） and in those with lymph nodes metastases（P = 0. 020）. There is no correlation between EphA1 expression and other clinical parameters. Conclusion： These data imply that EphA1 gene could promote the progression of gastric cancer.