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血栓对ST段抬高心肌梗死患者介入治疗后的严重影响

Effect of thrombosis on intervention therapy outcome in patients with ST-segment elevation myocardial infarction
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摘要 目的探讨ST段抬高心肌梗死(ST-Segment Elevation Myocardial Infarction,STEMI)置入药物洗脱支架(Drug-eluting stent,DES)后、血栓负荷对临床预后和梗死相关血管支架内血栓形成(Infarct-related artery stent thrombosis,IRA-ST)的影响。方法回顾性分析100例置入DES的STEMI患者,血管造影评价了冠状动脉内的血栓负荷,并按血栓大小分为大血栓负荷(Large thrombus burden,LTB)和小血栓负荷(Small thrombus burden,STB),血栓负荷大于2倍血管直径为LTB,小于2倍血管直径的为STB,以此评价血栓大小对临床预后的影响。主要心血管不良事件(Major adverse cardiac events,MACE)包括死亡、再发心肌梗死、心机梗死相关血管再次介入治疗。结果均随访12个月。LTB组MACE和IRA-ST较STB组高。结论在经DES治疗的STEMI患者中,LTB是MACE和IRA-ST独立预测因子。 Objective To investigate the impact of thrombus burden on the clinical outcome and angiographic infarct - related artery stent thrombosis (IRA- ST) in patients routinely treated with drug- eluting stent (DES) implantation for ST- segment elevation myocardial infarction (STEMI). Methods We retrospectively analyzed 100 consecutive patients treated with DES implantation for STEMI. Intracoronary thrombus burden was angiographically estimated and categorized as large thrombus burden (LTB), defined as thrombus burden greater than 2 - fold vessel diameters, and small thrombus burden (STB) to predict clinical outcomes. Major adverse cardiac events (MACE) were defined as death, repeat myocardial infarction, and IRA reintervention. Results Mean duration of follow - up was 12 months. The incidences MACE and IRA - ST in LTB group were higher than in STB group. Large thrombus burden was an independent predictor of mortality and MACE. Conclusions Large thrombus burden is an independent predictor of MACE and IRA - ST in patients treated with DES for STEMI.
出处 《武警医学》 CAS 2009年第7期585-587,共3页 Medical Journal of the Chinese People's Armed Police Force
关键词 心肌梗死 药物支架 支架内血栓 Myocardial infarction Drug- eluting stent Stent thrombosis
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参考文献9

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