摘要
目的探讨小剂量、短疗程、个体化的免疫抑制及抗凝疗法在抗心磷脂抗体(anticardiolipin antibody,ACL)阳性脑梗塞二级防治中的有效性和安全性。方法采用标准对照研究方法随访观察标准组(即单纯阿司匹林治疗组,共27例)、对照1组(即阿司匹林联合激素治疗组,共31例)及对照2组(即阿司匹林联合激素及肝素钠治疗组,共34例)三组脑梗塞的再发事件,分析小剂量、短疗程、个体化的免疫抑制及抗凝疗法在ACL阳性脑梗塞二级防治中的有效性及安全性。结果在治疗后3年随防观察期内,标准组再发缺血性脑卒中(包括短暂性脑缺血发作和再发脑梗塞)再发事件发生率为37.04%(10/27),明显高于对照1组[6.45%(2/31)]和对照2组[2.94%(1/34)],P<0.01。三组均未见脑出血再发。结论小剂量、短疗程、个体化的免疫抑制和抗凝疗法对ACL阳性脑梗塞患者再发事件中的二级防治有效且安全。
Objective To outline the efficacy and safety of the secondary prevention and therapy with lowdose, short- course and individualized immunosuppressors and anticoagulants for cerebral infarction (CI) patients with positive-anticardiolipin antibody (ACL). Methods This study, including criterion group (namely group accepting therapeusis with aspirin, n = 27), control 1 (namely group accepting therapeusis with aspirin plus prednisone, n = 31), and control 2 (namely group accepting therapeusis with aspirin plus prednisone and heparin, n = 34), was carried out by means of analyzing recurrent events such as transient ischemic attack (TIA), recurrent CI (RCI), recurrent cerebral ischemic apoplexy (RCIA), and cerebral hemorrhage (CH) during the follow- up observation after treatment for cerebral infarction cases with positive- ACL. Results During 3 - year follow- up after treatment of all participants, the incidence of RCIA consisting of TIA and RCI in criterion group was 37.04 % (10/ 27), which was significantly higher than that in control 1 with 6.45% (2/31) and control 2 with 2.94% (1/34), P 〈0.01, while no patients of all three groups suffered with CH. Conclusion These results suggest that it is effective and safe for the secondary prevention and therapy with low-dose, short- course and individualized immuno- suppressors and anticoagulants for patients with CI associated with positive-ACL.
出处
《右江民族医学院学报》
2009年第4期567-569,共3页
Journal of Youjiang Medical University for Nationalities
关键词
抗体
抗心脂
脑梗塞
再发事件
二级防治
antibodies, anticardiolipin
brain infarction
recurrent event
the second prevention and therapy