GRPR基因多态性与ADHD多动行为关系的研究

A study on relationship between GRPR gene polymorphism and hyperactivity behaviors of children with ADHD

目的探讨胃泌素释放肽受体基因多态性和注意力缺陷多动障碍行为的关系。方法通过Achenbach儿童行为量表，将120例符合美国《精神障碍诊断与统计手册》第4版诊断的注意力缺陷多动障碍患儿和126例正常儿童，按胃泌素释放肽受体第2外显子基因多态性分成CC组和非CC组，分析其社会适应行为中多动行为的特点及治疗后的变化。结果正常对照儿童CC和非CC组儿童行为量表问卷的多动分值经比较无显著性差异（F=1．97，P〉0．05）；注意力缺陷多动障碍患儿基因型CC组儿童行为量表问卷的多动分值明显低于非CC组（F=37．27，P〈0．01）。部分患儿在治疗6个月和1年后，儿童行为量表随诊结果仍为CC组低（F分别为36．52、42．13，均P〈0．01）。结论胃泌素释放肽受体第2外显子基因多态性对注意力缺陷多动障碍的多动行为有一定的影响。

Objective To investigate relationship of gastrin-releasing peptide receptor （GRPR） gene polymorphism with behaviors of children with attention deficit hyperactivity disorder （ADHD）. Methods 126 normal children and 120 children with ADHD who met the DSM-1V diagnostic creteria were divided into two groups ： CC group and non-CC group according to polymorphisms of the second exon gene of GRPR. All of them were interviewed and investigated with Aehenbaeh child behavior chicklist （CBCL） for their characteristics of hyperactivity behavoirs in social adaptive behavoirs and changes in hyperactivity behavoirs after treatment, and the results were compared. Results In scores in hyperactivity by CBLB, there were not significant difference between CC subgroup and non-CC subgroup in the control group （ F = 1.97, P 〉 0.05 ）. The scores in hyperactivity of genotype CC in ADHD group were lower than non-CC group （ F = 37.27, P 〈 0.01 ）. After half and one year＇ s treatment, the results of parts of them were the same at follow up （ F = 36.52, P 〈 0.01 ; F = 42.13, P 〈0.01 ）. Conclusion The polymorphism of the second exon gene of GRPR maybe cause hyperactivily behaviors of children with ADHD.