普罗布考对急性脑梗死患者血浆高敏C反应蛋白和血小板聚集率的影响

Effect of probucol on functions of C-reactive protein and rate of platelet aggregation of patients with acut cerebral infarction

目的观察普罗布考对急性脑梗死患者高敏C反应蛋白和血小板功能的影响。方法56例急性脑梗死患者按入院顺序随机分为治疗组和对照组各28例。治疗组在常规治疗的基础上加普罗布考0.5g,2次/d,连续30d,并于治疗前后进行神经功能评估(NIHSS评分)与高敏C反应蛋白和血小板功能测定。结果普罗布考治疗后在神经功能改善的同时,能够降低高敏C反应蛋白并且血小板功能亦得以改善。结论普罗布考具有降低C反应蛋白和改善血小板功能的作用。

Objective To observe the clinical efficacy of probucol and its effect on functions of C-reactive protein and rate of platelet aggregation of patients with aeut cerebral infarction. Methods 56 patients with acute cerebral infarction were equally and randomly divided to control group （ receive routine therapy ） and treatment group （ receive routine therapy plus 0. 5 g probucol, bid, for 30 days）. The neurological function （NIHSS） was evaluated and the C-reactive protein and rate of platelet aggregation were measured before and after treatment. Results After treatment, C-reactive protein and rate of platelet aggregation were markedly improved following improvement in neurological function. Conclusion Probucol possesses the effects of reduce C- reactive protein and rate of platelet aggregation.