替米沙坦与氨氯地平联合治疗高血压79例临床观察

CLINICAL OBSERVATION OF TELMISARTAN AND AMLODIPINE IN TREATING 79 CASES WITH HYPERTENSION

目的探讨联合应用替米沙坦和氨氯地平治疗轻中度原发性高血压的疗效。方法选择79例Ⅰ级、Ⅱ级高血压患者,经2周停药清洗后,给予口服替米沙坦60mg,氨氯地平5mg,每日7:00顿服,8周为1个疗程。用药前及治疗8周后行动态血压监测,观察患者24h平均血压、日间平均血压、夜间平均血压、10:00血压及谷峰比值的变化。结果治疗8周后,24h平均收缩压和舒张压、日间平均收缩压和舒张压、夜间平均收缩压和舒张压及10:00血压均显著下降。治疗后收缩压谷峰比值为75%,舒张压谷峰比值为73%。结论联合应用替米沙坦和氨氯地平可在满意降低患者血压的同时控制血压晨峰现象并降低24h血压波动幅度。

Objective To investigate the effect of combination of telmisartan and amiodaronein in patients with hypertesion. Methods 79 patients with stage 1 or stage 2 hypertension were treated with a fixed dose combination of telmisartan 60mg and amlodipine 5mg, once daily for 8 week. 24h ambulatory blood pressure monitoring （ABPM） was performed before and after treatment to monitor the mean systolic blood pressure （SBP）, the mean diastolic blood pressure （DBP）, day time blood pressure （DTBP）, night time blood pressure （NTBP） and blood pressure at A. M. 10：00. The peak ratio index（P/R） were calculated by computer. Results The mean systolic blood pressure （SBP） and diastolic blood pressure （DBP） in 24h, day time blood pressure （DTBP） and night time blood pressure （NTBP） all had a significant reduction （P〈0. 05）. T/P ratio of systolic blood pressure and diastolic blood pressure is 75% and 73% after treatment. Conclusion The combination of amlodipine and telmisartan is effective to reduce blood pressure and blood pressure fluctuations.