29例严重药品不良反应报告分析

Analysis of 29 serious ADR cases

目的:了解严重药品不良反应(ADR)发生的特点和规律,促进ADR监测,为临床安全用药提供参考。方法:收集我院2006年11月～2008年12月报告的29例严重ADR病例,按ADR发生的关联性因素进行统计、分析与评价。结果:本组资料中,引起严重ADR的前两位药品是抗感染药和中药注射剂,其中喹诺酮类药物引起中枢神经系统损害、中药注射剂引起过敏性休克和呼吸系统损害较多见;静脉给药是引起严重ADR最多的给药途径;多见于并用3种或以上药品的病例。结论:重视ADR监测工作,特别是抗感染药和中药注射剂的安全性监测;加强临床合理用药,以减少严重ADR的发生。

Objective： To investigate the characteristics and disciplinarian of serious adverse drug reactions （ADR） and to promote ADR monitoring so that to guide clinical practice. Methods： From November 2006 to December 2008, we elleeted 29 severe ADR cases in our hospital, analyzed statistically and evaluated based on the ADR causality judgment criteria. Results： The antibiotics and traditional Chinese medicine injection caused the higher proportion of serious ADR. The quinolones harmed to central nervous system and the traditional Chinese medicine injection eansed irritability shock or harmed to breath system. Injection is the main way for administration, and most of them were combined more than three drugs. Conclusion： Great importance should be attached to the safety monitoring of antibiotics and traditional Chinese medicine injection, and improve rational drug use to guard against severe ADR.