PCNA、Ki-67及VEGF在淋巴结肿大疾病中表达差异的临床价值

Investigation of expression of PCNA,Ki-67 and VEGF in Lymphadenectasis diseases

目的探讨增殖细胞核抗原(PCNA)、Ki-67、血管内皮生长因子(VEGF)在淋巴结炎症性肿大、反应增生性肿大、肿瘤性肿大(恶性淋巴瘤)3大类淋巴结肿大疾病中的表达水平及其意义。方法S-P免疫组织化学染色法检测PCNA、Ki-67、VEGF蛋白在上述3组病例中的表达水平。结果在所检测的3组淋巴结肿大疾病中PCNA、Ki-67、VEGF均有不同程度的阳性表达,肿瘤组明显高于其他两组(P<0.05),炎症组和反应增生组之间差异无统计学意义(P>0.05)。结论PCNA、Ki-67、VEGF在肿瘤性和非肿瘤性淋巴结肿大疾病中表达有差异,可作为鉴别淋巴结肿瘤性肿大的辅助指标之一。

Objective To investigate the expression of PCNA,Ki-67 and VEGF in 3 types of lymphadenectasis diseases,inclu ding lymphadenitis,reactive hyperplasia of lymph node and malignant Iymphoma. Methods To detect the expression levels of the proteins of PCNA,Ki-67 and VEGF by S-P immunohistochemistry method in 3 types of lymphadenectasis diseases. Results In 84 detected specimens,PCNA, Ki-67 and VEGF expressed in different levels in these 3 types of lymphadenectasis diseases. The positive expression rates of PCNA,Ki-67 and VEGF in oncosis group were significantly higher than those in others （P〈0.05）. The difference between inflammation group and hyperplasia group was not significant （P〉0.05）. Conclusion The expressive difference of PCNA,Ki-67 and VEGF in 3 types of lymphadenectasis diseases can be a subsidiary index that distinguish nonmalignant with malignant diseases