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蛋白激酶CK2与DNA断裂修复

Protein Kinase CK2 and DNA Strand Break Repair
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摘要 蛋白激酶CK2（酪蛋白激酶Ⅱ）是真核细胞中普遍存在的一种信使非依赖的丝氨酸／苏氨酸蛋白激酶，它底物众多，功能广泛。DNA断裂修复是一个涉及很多种酶和蛋白的过程，CK2在其中起着很重要的作用。 Protein casein kinase 2 （CK2） is a ubiquitous eukaryotic messenger-independent serine/threonine kinase. It possesses a lot of substrates and plays various roles in cells. Chromosomal DNA strand break repair involves a large number of enzymes and proteins, among which CK2 plays a critical role.
作者 焦瑾(综述) 刘新光(审阅)
机构地区 广东医学院生物化学与分子生物学研究所 广东医学院检验医学研究所
出处 《医学分子生物学杂志》 CAS CSCD 2009年第4期335-338,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金（No.30672205,30871440）,广东省高等学校自然科学研究重点项目（No.062015）,湛江市科技局招标项目（No.ZZ0605）
关键词 蛋白激酶CK2 DNA单链断裂修复 DNA双链断裂修复 protein kinase CK2 DNA single-strand break repair DNA double-strand break repair
分类号 Q555.7 [生物学—生物化学]
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参考文献20

  • 1ILES N,RULTEN S,EL-KHAMISY S F,et al.APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks[J].Mol Cell Biol,2007,27(10):3793-3803.
  • 2AYOUB N,JEYASEKHARAN A D,BERNAL J A,et al.HP1-βmobilization promotes chromatin changes that initiate the DNA damage response[J].Nature,2008,453(29):682-686.
  • 3CHAPMAN J R,JACKSON S P.Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage[J].Eur Mol Biol,2008,9(8):795-801.
  • 4LOU D Y,DOMINGUEZ I,TOSELLI P,et al.The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development[J].Mol Cell Biol,2008,28(1):131-139.
  • 5SINGH N N,RAMJI D P.Protein kinase CK2,an important regulator of the inflammatory response[J].J Mol Med,2008,86(8):887-897.
  • 6谢成英(综述),蔡育军,丁健(审校).DNA损伤与肿瘤发生的研究进展[J].中国癌症杂志,2006,16(4):313-317. 被引量：16
  • 7黄敏,缪泽鸿,丁健.DNA双链断裂损伤修复系统研究进展[J].生理科学进展,2007,38(4):295-300. 被引量：13
  • 8CALDECOTE K W.DNA single-strand break repair and spinocerebellar ataxia[J].Cell,2003,112:7-10.
  • 9BREM R,HALL J.XRCC1 is required for DNA single-strand break repair in human cells[J].Nucleic Acids Res,2005,33(8):2512-2520.
  • 10TAKAHASHI T,TADA M,IGARASHI S,et al.Aprataxin,causative gene product for EAOH/AOA1,repairs DNA single-strand breaks with damaged 30-phosphate and 30-phosphoglycolate ends[J].Nucleic Acids Res,2007,35(11):3797-3809.

二级参考文献79

  • 1Abraham RT.Cell cycle checkpoint signaling through the ATM and ATR kinases[J].Genes Develop,2001,15(17):2177-2196.
  • 2Kastan MB,Zhan Q,El-Deiry WS,et al.A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia[J].Cell,1992,71(4):587-597.
  • 3Cohen JJ,Duke RC,Sellins KS,et al.Apoptosis and programmed cell death in immunity[J].Annu Rev Immunol,1992,10:267-293.
  • 4Durocher D,Jackson SP.DNA-PK,ATM and ATR as sensors of DNA damage:variations on a theme[J].Curr Opin Cell Biol,2001,13(2):225-231.
  • 5Norbury CJ,Zhivotovsky B.DNA damage-induced apoptosis[J].Oncogene,2004,23(16):2797-2808.
  • 6Lee JH,Paull TT.ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex[J].Science,2005,308(5721):551-554.
  • 7Uziel T,Lerenthal Y,Shiloh Y,et al.Requirement of the MRN complex for ATM activation by DNA damage[J].EMBO J,2003,22(20):5612-5621.
  • 8Wang JYJ.Cellular responses to DNA damage[J].Curr Opin Cell Biol,1998,10(2):240-247.
  • 9Cortez D,Guntuku S,Elledge SJ.ATR and ATRIP:partners in checkpoint signaling[J].Science,2001,294(5547):1713-1716.
  • 10Momand J,Wu HH,Dasgupta G.MDM2-master regulator of the p53 tumor suppressor protein[J].Gene,2000,242(1-2):15-29.

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医学分子生物学杂志
2009年 第4期

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