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新型GATA-1相互作用蛋白质及其在造血调控中的作用 被引量：1

Novel GATA-1 Interacting Proteins and Their Roles in Hematopoietic Regulation
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摘要 GATA-1在造血干细胞的谱系分化中起关键的调控作用，为红系和巨核系发育成熟必不可少，对肥大细胞系及嗜酸性粒细胞系发育也有一定的调控作用。GATA-1的转录活性受到多层次的精确调节，其调控不同谱系分化的功能大多通过与不同的蛋白质相互作用来实施。近年来，多种新的GTAT-1相互作用蛋白质被确定，特别是GATA-1复合体的研究，揭示了GATA-1转录活性及其调控造血分化的新机制。 GATA-1, a zinc finger transcription factor specifically expressed in hemopoietic cells, is essential for erythroid and megakaryocytie development, and also plays key roles in mast cells and eosinophils. The transcriptional activity and function of GATA-1 are modulated by a complex network of factors, especially its interacting proteins. Nowadays, many new proteins have been identified as interacting partners of GATA-1, including protein complexes, therefore leading to novel mechanisms for transcriptional activity and hematopoietic regulation of GATA-1.
作者 丁亚丽 李长燕 杨晓明
机构地区 军事医学科学院放射与辐射医学研究所
出处 《医学分子生物学杂志》 CAS CSCD 2009年第4期339-342,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金（No.30630035,30570781）
关键词 GATA-1 Gfi-1b ZNF521 runt相关转录因子1 ZBP-89 GATA-1 growth factor independence-lb zinc finger protein 521 runt-related transcription factor 1 zinc finger binding protein 89
分类号 Q51 [生物学—生物化学]
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参考文献15

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医学分子生物学杂志
2009年 第4期

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