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NHERF1／EBPSO在肿瘤发生发展中的作用

Role of NHERF1/EBP50 in Cancer Occurrence and Development
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摘要 钠氢交换子调节因子1（Na＋／H＋ exchanger regulating factor1，NHERF1）是由358个氨基酸组成的多功能连接蛋白。NHERF1通过其PDZ-1、PDZ-2和EB结构域与多种蛋白质结合，对PDGF、P13K／Akt等信号转导通路起到调控作用。目前研究发现，NHERF1在多种肿瘤中存在异常表达和定位，并且通过与多种抑癌蛋白的相互作用参与肿瘤的发生。文章综述了NHERF1结构、定位、以及在肿瘤（如乳腺癌和肝癌）中的作用机制。 Na＋/H＋ exchanger regulating factor 1 （NHERFI） is a muhifunctional connectin which is composed of 358 amino acids. It associates with various proteins via its PDZ-1, PDZ-2 and EB domains and acts as a regulator of PDGF and P13K/Akt signal transduction pathway. Recent studies have suggested that NHERF1 is expressed and located abnormally in different cancers. Furthermore, NHERF1 has been found to interact with some tumor suppressor proteins, thus being involved in tumorigenesis. This review introduces the structure and cellular location of NHERF 1, and its role in development of cancer, such as breast cancer and liver cancer.
作者 冯灿(综述) 刘亚伟(审阅)
机构地区 第二军医大学长征医院内科学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2009年第4期353-356,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金面上项目（No.30771016）
关键词 钠氢交换子调节因子1 乳腺癌 肝癌 Na＋/H＋ exchanger regulating factor 1 breast cancer liver cancer
分类号 Q51 [生物学—生物化学]
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参考文献27

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医学分子生物学杂志
2009年 第4期

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