β-arrestin和信号转导

β-Arrestin and Signal Transduction

β-arrestin是一类重要的信号调控蛋白和支架蛋白（scaffold）。在G蛋白偶联受体（G-protein-OOU-piedreceptor，GPCR）信号转导中，β-arrestin不但可以作为GPCR信号的负性调控分子，还能作为支架蛋白促进GPCR对其他信号通路的激活，如有丝分裂原激活蛋白激酶（mitogen-activated protein kinase，MAPK）途径。另外β-arrestin还能与转录因子调节蛋白，如IKB和Mdm2相互作用问接调节NF-κB和P53介导的转录。

β-arrestins are a family of important signaling adapter proteins and scaffold proteins. β-arrestins function not only as negative regulators of G-protein-coupled receptor （GPCR） signaling transduction, but also as scaffold proteins that promote other signaling pathways, such as Mitogen- activated protein kinase （MAPK） activated by GPCR. In addition, β-arrestin interacts with regulators of transcription factors, such as IKB and MDM2, and regulates indirectly transcription of NF-κB and p53.