摘要
背景:细胞凋亡异常在肿瘤发生中起重要作用,抑凋亡基因Bcl-2和促凋亡基因Bax与细胞凋亡密切相关。目的:探讨Bcl-2和Bax在胃癌中的表达及其意义。方法:采用免疫组化SP法检测30例慢性非萎缩性胃炎、30例慢性萎缩性胃炎和30例胃癌黏膜组织中Bcl-2和Bax表达水平。结果:慢性非萎缩性胃炎组Bcl-2和Bax表达阳性率与慢性萎缩性胃炎组相比无明显差异(Bcl-2:36.7%对43.3%,Bax:33.3%对50.0%,P>0.05),但均显著低于胃癌组(分别为66.7%和80.0%,P<0.05)。结论:Bcl-2和Bax在胃癌中的表达明显增加,提示两者可能在胃癌的发生、发展中起重要作用。
Background： Cell apoptosis plays an important role in the development of tumor, and anti-apoptotic gene Bcl-2 and proapoptotic gene Bax are closely associated with cell apoptosis. Aims： To investigate the expressions of Bcl-2 and Bax and their significances in gastric cancer. Methods： Immunohistochemical SP method was used to measure the expressions of Bcl-2 and Bax in mucosal tissues of 30 chronic non-atrophic gastritis, 30 chronic atrophic gastritis and 30 gastric cancer. Results： No significant differences of the positivity rates of Bel-2 and Bax expressions were found between chronic non-atrophic gastritis group and chronic atrophic gastritis group （Bcl-2： 36.7% vs. 43.3%, Bax： 33.3% vs. 50.0%, P〉0.05）, but both of them in the two gastritis groups were significantly lower than those in gastric cancer group （Bcl-2： 66.7%, Bax： 80.0%, P〈0.05）. Conclusions： The expressions of Bcl-2 and Bax were increased in the gastric cancer, which suggest that both of them may play important roles in the pathogenesis and development of gastric cancer.
出处
《胃肠病学》
2009年第6期365-366,共2页
Chinese Journal of Gastroenterology
