良性前列腺增生与血脂异常

The correlation between lipid abnormality and benign prostatic hyperplasia in men receiving physical examination

目的探讨体检人群中老年人良性前列腺增生（BPH）与血脂异常的相关性。方法选择在我院体检的中老年男性共401例，通过现场询问病史，国际前列腺症状评分（IPSS），直肠指诊，经直肠B超分为两组：（1）BPH组192例；（2）非BPH组209例。比较两组血脂水平及危险分层差异。结果两组血脂水平[三酰甘油（TG）：t=0．388，P=0．698；总胆固醇（TC）：t=0．449，P=0．654；低密度脂蛋白胆固醇（LDL—C）：t=0．151，P=0．880；高密度脂蛋白胆固醇（HDL—C）：t=0．628，P=0．531）]、心血管病综合危险的评价分层（χ^2=4．094，P=0．251）差异均无统计学意义；IPSS评分与血脂异常亦无明显相关性（TG：χ^2=5．855，P=0．054；TC：χ^2=3．813，P=0．149；LDL—C：χ^2=1．704，P=0．427；HDL—C：χ^2=3．289，P=0．193）。结论BPH并存血脂异常临床多见，但在BPH下尿路症状以轻中度为主的体检人群中，二者之间的相关性不如以需手术治疗的中重度BPH患者为纳入人群的类似研究关系明确，其机理尚有待进一步研究证明。

Objective To investigate the relationship between lipid abnormality and benign prostatic hyperplasia （BPH） in men receiving physical examination. Methods Four hundred and one people who participated health examination in our hospital in May 2008 were included in the study. They were divided into two groups according to history of disease, IPSS score, the results of digital rectal examination and transrectal ultrasound： BPH group （192 cases） and no BPH group （209 cases）. The blood lipid level and risk factors were compared in two groups. Results There were no statistical differences in blood lipid level and risk stratification of cardiovascular disease between the two groups （TG：P=0. 698;TC：P=0. 654;LDL C：P=0. 880;HDL-C：P=0. 531; risk stratification： P= 0. 251）. IPSS score had no obvious correlation with blood lipid level （TG： P = 0. 054; TC= P = 0. 149; LDL-C： P = 0. 427; HDL-C： P = 0. 193 ） . Conclusions BPH complicated with lipid abnormality is common in the clinics, but the correlation between BPH and lipid abnormality in patients with light BPH is not so clear as that in patients with mild or severe BPH.