老年性痴呆合并脑白质疏松症患者临床特点

cognitive impairment in patients of Alzheimer's disease with leukoaraiosis

【目的】探讨老年性痴呆合并脑白质疏松症(LA)患者的临床特点。【方法】收集AD患者103例,检测受试者的血压、血糖、血脂、体重指数、受教育程度等信息,并通过头颅CT或MRI检查确定是否存在LA,对比分析老年性痴呆合并LA及不合并LA组的临床特征及认知功能下降的情况。认知功能的检测用简易智力状态检查(mini-mental state examination,MMSE)。【结果】103例AD患者中57人检查证实合并LA,与不合并LA的46例患者比较,合并LA的患者患有冠心病(P<0.05)、颈动脉狭窄(P<0.05)的比例更高,而且认知功能下降的程度更明显(P<0.01)。【结论】我们的研究提示,冠心病和颈动脉狭窄是AD合并LA发生的可能危险因素,LA的发生加重AD的认知损害。

[Objective] To study the clinical feature of Alzheimer＇ s disease with leukoaraiosis （LA） . [Methods] we enrolled 103 cases of patients of AD, LA was diagnosed through the head CT or MRI examination. Blood pressure, blood glucose, blood lipids, body mass index, educational level and other information was collected. [Results] Compared with patients without LA , patients with LA have higher proportion of coronary heart disease （P 〈 0.05） and carotid artery stenosis （P 〈 0.05） and worsen cognitive function （P 〈 0.01） [Conclusions] Our study suggests coronary heart disease and carotid artery stenosis are possible risk factors of AD with LA. LA may Aggravate cognitive impairment of AD.