活性维生素D与24h尿钙相关性研究

Relevance on active vitamin D and 24-hour urinary calcium

目的对连续服用活性维生素D 6个月与不定期服用该药治疗骨质疏松患者,测24 h尿钙定量并比较。方法47例骨质疏松患者连续服用维生素D 6个月为治疗组,37例间断服用活性维生素D 6个月为对照组。美国RUNAR双能X线骨密度仪测定骨密度;美国强生VIPROS 250仪器干化学法测24 h尿钙定量;德国罗氏MODULAR PPISE 900仪器酶速率法测定血液生化指标。结果治疗组与对照组相比较,差异无显著性（P〉0.05）。结论肝肾功能正常的骨质疏松患者,生理剂量内活性维生素D连续服用6个月,对机体是安全的。

Objective To investigate the impact of oral active vitamin D for 6 months on 24-hour urinary calcium. Methods The treatment group was 47 osteoporosis patients who continuously take active vitamin D for 6 months, the 37 cases were the control group for inter-segment taking active vitamin D 6 months. Levels of bone mineral density were measured, the quantitative 24-hour urinary calcium and blood biochemical parameters were all measured. Results The treatment group were of no significant difference compared with the control group, P 〉 0.05. Conclusion The patients with osteoporosis who have normal liver and renal function, continuously take physiological doses of active vitamin D, it is safe.