高分辨显微CT技术进展

Technology Development of Micro-CT with High Spatial Resolution

显微CT是一种新型的采用X射线成像原理进行高分辨三维成像的设备。可以在不破坏样品的情况下,对骨骼、牙齿和各种生物材料等离体标本进行高分辨三维成像。近年来,更多地用于小动物活体成像,用于药物开发,肿瘤病理学和基因显型研究。本文围绕显微CT的技术手段进行综述,总结了它的现状和几个重要发展方向,高成像对比度、超高分辨率、快速实时以及多模态成像。

Micro-computed tomography （Micro-CT） is a new three-dimension high-resolution imaging device based on X-ray imaging principle. The system enables a non-invasive three-dimensional inspection to the specimen, bones, teeth and biomaterial, and in latest year, it was more widely applied to screen small animal in vivo for drug discovery, cancer pathology and gene expression research. This review describes the technical aspects of Micro-CT, and indicates four main development directions, improved imaging contrast, ultra-high spatial resolution, fast speed and multi-modality imaging.