硫酸沙丁胺醇药物树脂的制备及其影响因素考察

Preparation and influence factors of salbutamol sulfate resin

目的：制备硫酸沙丁胺醇药物树脂，并对影响因素（粒径、浓度、温度、交联度、流速）进行考察。方法：静态载药法和动态载药法。结果：静态载药的优化条件是温度为25℃，药物浓度为6mg·mL^-1，树脂粒径为180～240目；动态载药的优化条件是温度为30℃，药物浓度为8mg·mL^-1，树脂粒径为180～240目，流速1mL·min。结论：采用静态载药法制备硫酸沙丁胺醇药物树脂。

Ojective：To prepare salbutamol sulfate resins and evaluate the factors that affect the preparation. Methods：Bath method and column method were utilized. Results：The preparation of salbutamol sulfate resins using the bath method was optimized with drug concentration of 6 mg·mL-1 and resin particle size of 180 - 240 mesh at 25℃. The optimal conditions of the column technique were drug concentration of 8 mg·mL^-1 and resin particle size of 180 - 240 mesh at 25 ℃ , and the efflux speed at 1 mL·min^-1. Conclusion ： Salbutamol sulfate resins could be prepared by bath method.