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系统性红斑狼疮患者血清HMGB1水平检测及临床意义 被引量：1

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摘要 目的了解系统性红斑狼疮(SLE)患者血清中高迁移率族蛋白1(high mobility group box1,HMGB1)的水平,探讨其在SLE发病机制中的作用。方法选择SLE患者60例,根据SLEDAI评分,分为活动组(≥10分)和稳定组(<10分)各30例,健康志愿者20例作为对照组。采用ELISA方法检测各组患者血清中HMGB1水平。采用统计学方法分析其与SLE临床及实验室指标之间的相关性。结果活动期SLE患者HMGB1血清水平较正常和稳定期SLE患者表达水平明显升高,差异有统计学意义(P<0.001),而稳定组与健康对照组的差异无统计学意义(P>0.05)。血清HMGB1水平与SLEDAI、24h尿蛋白水平、抗C1q抗体、抗核小体抗体成正相关(P<0.05),与C4成负相关(P<0.05),抗ds-DNA抗体阴性组与阳性组HMGB1浓度的差异有统计学意义。但与感染、淋巴细胞百分比、血沉、C反应蛋白、C3、抗RNP抗体、抗SSA或SSB抗体等无明显相关性。结论活动期SLE患者血清HMGB1水平升高,且与疾病活动指标具有相关性,提示HMGB1可能作为促炎因子在SLE的发病中起重要作用。
作者 夏江莉 李向培 钱龙 厉小梅 汪国生 马艳 张宏
机构地区 安徽医科大学附属省立医院风湿免疫科
出处 《临床输血与检验》 CAS 2009年第3期242-245,共4页 Journal of Clinical Transfusion and Laboratory Medicine
关键词 高迁移率族蛋白1 红斑狼疮 系统性 炎症
分类号 R593.24 [医药卫生—内科学]
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参考文献10

  • 1Mok C C,Lau C S.Pathogenesis of systemic lupus erythematosus[].Journal of Clinical Pathology.2003
  • 2Pullerits R,Jonsson IM,Verdrengh M,et al.High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis[].Arthritis and Rheumatism.2003
  • 3Andersson U,Tracey K J.HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis[].Rheumatic Disease Clinics of North America.2004
  • 4Fiuza C,Bustin M,Talwar S,et al.Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells[].Blood.2003
  • 5Kokkola R,Andersson A,Mullins G,et al.RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages[].Scandinavian Journal of Immunology.2005
  • 6Bierhaus A,Schiekofer S,Schwaninger M,et al.Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB[].Diabetes.2001
  • 7Yamamoto Y,Kato I,Doi T,et al.Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice[].Journal of Clinical Investigation The.2001
  • 8Tanji N,Markowitz G S,Fu C,et al.Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease[].Journal of the American Society of Nephrology.2000
  • 9M Ek,K Popovic,HE Harris,CS Naucler,M Wahren-Herlenius.Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sj?gren’s syndrome[].Arthritis and Rheumatism.2006
  • 10Ulfgren,AK,Grundtman,C,Borg,K.Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids[].Arthritis and Rheumatism.2004

同被引文献29

  • 1Urbonaviciute V, Fumrohr BG, Weber C, et al. Fators masking HMGB1 in human serum and plasma[J]. Leukoc Biol, 2007, 81 : 67-741.
  • 2Wang Q, Zeng M, Wang W, et al. The HMGB1 acidic tail regulates HMGB1 DNA binding specificity by a unique mcha-nism[J].Biochem Biophys Res Commun, 2007, 360: 14-19.
  • 3Mosevitsky MI, Novitskaya VA, et al. Tissue specificity of nu- cleo-cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions[J]. Eur J Biochem, 1989, 185(2): 303- 310.
  • 4Ziekert A, Palmblad K, Sundelin B, et al. Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis[J]. Arthritis Res Ther, 2012, 14( 1 ) : R36.
  • 5Abdulahad DA, Westra J, Bijzet J, et al. High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus [J]. Arthritis Res Ther, 2011, 13(3): R71.
  • 6Ma CY, Jiao YL, Zhang J, et al. Elevated plasma level of HMGB1 is associated with disease activity and combined altera- tions with IFN-alpha and TNF-alpha in systemic lupus erythe- matosus[J]. Rheumatol Int, 2012, 32(2): 395-402.
  • 7Li J, Xie H, Wen T, et al. Expression of high mobility group box chromosomal protein 1 and its modulating effects on down- stream cytokines in systemic lupus erythematosus[J]. Rheumatol, 2010, 37(4): 766-775.
  • 8Ma CY, Ma JL, Jiao YL, et al. The plasma level of soluble receptor for advanced glycation end products is decreased in patients with systemic lupus erythematosus[J]. Scand J I mmunol, 2012, 75(6): 614-622.
  • 9Park JS, Svetkauskaite D, He Q, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein[J]. Biol Chem, 2004, 279(9): 7370-7377.
  • 10Campana L, Bosurgi L, Bianchi ME, et al. Requirement of HMGB1 for stromal cell-derived factor-1/CXCL 12-dependent migration of macrophages and dendritic cells[J]. Leukoc Bid, 2009, 86(3): 609-315.

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临床输血与检验
2009年 第3期

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