肠黏膜屏障损伤的原因与机制研究进展

Advance in causes and mechanisms of intestinal injury

最新研究发现,临床上许多疾病的发生、发展与转归都与肠黏膜屏障损伤有关,因而肠黏膜屏障损伤的原因与机制越来越引起临床医师的重视.引起肠黏膜屏障损伤的常见原因与机制有缺血缺氧、缺血-再灌注、炎症介质、细菌内毒素、肠道菌群失调、免疫异常、营养障碍及全胃肠外营养(total parenteral nutrition,TPN)、严重创伤、全身及胃肠道严重感染等,本文就此作一综述.

New evidence suggests that intestinal barrier injury contributes to many diseases＇ occurrence, development and outcome in clinics. Therefore, the causes and mechanisms of intestinal mucosal barrier damage are attracting more and more attention from clinicians. Many causes may induce damages of the intestinal mucosal membrane barrier, including ischemia, anoxia, ischemia/reperfusion, inflammatory mediator infiltration, bacterial endotoxin release, imbalance of intestinal flora, immune abnormity, nutritional disturbance, total parenteral nutrition, severe trauma, general and gastrointestinal infection and so on. This article gives a review on the above causes and mechanisms.