氨假说和细胞因子在肝性脑病发病中的研究进展

Advance in roles of ammonia and cytokines in hepatic encephalopathy

氨假说被认为是肝损伤致肝性脑病重要机制之一.星状角质细胞水肿是肝性脑病的病理基础,而氨主要通过氧化应激激活、线粒体膜通透性转变和谷氨酰胺假说造成胶质细胞水肿.细胞因子对肝性脑病的发生也存在着影响.氨假说和细胞因子作用对肝性脑病的发生存在着一些共同机制.

Hyperammonia theory has been thought as a most feasible mechanism of hepatic encephalopathy following liver injury. Astroglial swelling was reckoned as pathological basis of hepatic encephalopathy. Many assumed mechanisms include oxidative stress activation, mitochondrial permeability transition and glutamine theory, by which ammonia acts on astroglial swelling. Cytokins have influence on the development of hepatic encephalopathy. There are mutual effects of both ammonia and cytokines inducing hepatic encephalopathy