菝葜根茎活性部位的抗炎作用及其对环氧化酶活性影响的研究

Affects on COX-1、2 Activities and Anti-inflammations Effects of the Smilax. China L Extraction

目的:研究菝葜水提醇沉物及其膜分离物对急性、慢性炎症的抗炎作用。方法:采用蛋清致足肿胀、甲醛致足肿胀、二甲苯致耳肿胀和醋酸致腹膜炎模型对菝葜不同提取物对急性、早期炎症的抗炎作用进行了研究。结果:在100g.生药/kg剂量下,提取物能显著降低蛋清诱导的大鼠足跖肿胀程度,明显抑制甲醛诱导的小鼠足肿胀程度、小鼠腹腔毛细血管通透性增高和二甲苯诱导的耳廓肿胀,对炎症晚期(慢性炎症)也有一定的抑制作用。结论:菝葜对急性、早期炎症具有明显的抗炎作用,对炎症晚期(慢性炎症)也有一定的抑制作用。

Objective：To study anti-inflammations on acute inflammation and chronic inflammation for Smilax. china L. Methods： The rat paw edema induced by egg-albumin, the ear edema and the foot edema of mice induced by xylene and formaldehyde, the increase of vascular permeability induced by intraperitoneal injection of 0. 7 % acetic acid in mice were used to study on the acute, early inflammations and chronic inflammation for the extract of s. china L. Results： The extract （100g. raw medicine/kg） can significantly decrease the rat paw edema for the inhibition effects on foot edema, inhibit the ear edema, vascular permeability increase and foot edema of mice and also display a certain extent inhibition effects on the granuloma induced by agar in mice that also exhibit their anti-inflammatory effects on the chronic inflammation. Conclusion： Smilax. china L