血清及支气管肺泡灌洗液肿瘤标志物测定对肺癌的诊断意义

Clinical significance of determination of tumor markers in serum and bronchoalveolar lavage fluid

目的探讨支气管肺泡灌洗液(BALF)和血清中肿瘤标志物细胞角蛋白19片段(CYFRA21-1),神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)含量在肺癌诊断过程中的变化、敏感程度及联合检测的意义。方法选择确诊的肺癌患者45例作为检测组,肺部良性病变患者45例作为对照组。使用酶联免疫吸附(ELISA)方法检测两组患者的BALF和血清中CYFRA21-1、NSE、CEA的含量。结果肺癌患者BALF及血清中CYFRA21-1、NSE、CEA浓度明显高于肺良性病变组(P<0.05),BALF中CYFRA21-1、NSE、CEA均高于血清中含量。结论肺癌患者BALF和血清中CYFRA21-1、NSE、CEA联合检测对肺癌诊断有较高的临床参考价值。

Objective To discuss the significance of CYFRA21 - 1, NSE and CEA in bronchoalveolar lavage fluid （BALF） in diagnosis, pathological type and stage of lung cancer. Methods 45 cases of lung cancer and 45 cases of benign lung diseases were enrolled as study group and control group respectively. Enzyme linked immunosorbent assay was used to detect the level of these three tumor markers in serum and BALF in these two groups. Results Levels of CYFRA21 - 1, NSE and CEA in serum and BALF of patients with lung cancr were higher than those of control group, and the difference was significant （ P 〈 0.05 ）. Conclusion Detecting levels of CYFRA21 - 1, NSE and CEA in BALFof patients with lung cancer have important significance in diagnosis of lung cancer.